Driving under the influence of drugs, alcohol, fatigue or stress are leading causes of road accidents, especially among commercial drivers such as truck, taxi, bus and courier service operators. These risks not only threaten the drivers’ safety but also the lives of others on the road. The PANACEA project is designed to tackle these challenges by developing tools to monitor and enhance drivers’ fitness to drive. By focusing on health-based, real-time assessments and support systems, the project aims to prevent accidents and improve overall road safety.